RNA-binding protein EWS

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2.^[5][6] It is one of 3 proteins in the FET protein family.^[7]

EWSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPE
Identifiers
Aliases	EWSR1, EWS, bK984G1.4, EWS-FLI1, Ewing sarcoma breakpoint region 1, EWS RNA binding protein 1
External IDs	OMIM: 133450; MGI: 99960; HomoloGene: 136069; GeneCards: EWSR1; OMA:EWSR1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 29,268,009 bp[1] End 29,300,525 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 5,069,689 bp[2] End 5,099,266 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis right testis right hemisphere of cerebellum right lobe of thyroid gland right adrenal cortex left adrenal cortex ganglionic eminence body of uterus left lobe of thyroid gland Top expressed in yolk sac neural layer of retina ventricular zone genital tubercle tail of embryo superior frontal gyrus primary visual cortex spermatocyte spermatid lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding calmodulin binding identical protein binding nucleic acid binding RNA binding Cellular component cytoplasm plasma membrane nucleolus membrane nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2130 14030 Ensembl ENSG00000182944 ENSMUSG00000009079 UniProt Q01844 Q61545 RefSeq (mRNA) NM_001163285 NM_001163286 NM_001163287 NM_005243 NM_013986 NM_001283061 NM_001283062 NM_001283063 NM_007968 RefSeq (protein) NP_001156757 NP_001156758 NP_001156759 NP_005234 NP_053733 NP_001269990 NP_001269991 NP_001269992 NP_031994 NP_001349541 NP_001349542 NP_001349543 NP_001349544 NP_001349545 NP_001349546 NP_001349547 NP_001349549 Location (UCSC) Chr 22: 29.27 – 29.3 Mb Chr 11: 5.07 – 5.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

The q22.2 region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several other chromosomes which encode various transcription factors; see EWS/FLI and OMIM-133450.^[8] The expression of a chimeric protein with the EWS transactivation domain fused to the DNA binding region of a transcription factor generates a powerful oncogenic protein causing Ewing sarcoma and other members of the Ewing family of tumors. These translocations can occur due to chromoplexy, a burst of complex chromosomal rearrangements seen in cancer cells. ^[9] The normal EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated to amyotrophic lateral sclerosis.^[10]

Interactions

The EWS protein has been shown to interact with:

• ATF1,^[11]
• BARD1,^[12]
• ERG,^[13]
• POU4F1,^[14]
• PTK2B^[15]
• SF1,^[16]
• SNRPC,^[17] and
• ZNF165.^[18]