RNF11

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.^[5][6][7]

RNF11
Identifiers
Aliases	RNF11, SID1669, CGI-123, ring finger protein 11
External IDs	OMIM: 612598; MGI: 1352759; HomoloGene: 32195; GeneCards: RNF11; OMA:RNF11 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 51,236,273 bp[1] End 51,273,447 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 109,308,295 bp[2] End 109,341,925 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus endothelial cell prefrontal cortex pars compacta external globus pallidus pars reticulata dorsolateral prefrontal cortex superior vestibular nucleus monocyte Brodmann area 9 Top expressed in blood lateral septal nucleus tibiofemoral joint cardiac muscle tissue of left ventricle ventromedial nucleus cingulate gyrus CA3 field perirhinal cortex subcutaneous adipose tissue central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase activity zinc ion binding Cellular component ubiquitin ligase complex cytoplasm recycling endosome endosome early endosome extracellular exosome nucleus Biological process ubiquitin-dependent protein catabolic process protein autoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26994 29864 Ensembl ENSG00000123091 ENSMUSG00000028557 UniProt Q9Y3C5 Q9QYK7 RefSeq (mRNA) NM_014372 NM_013876 RefSeq (protein) NP_055187 NP_038904 Location (UCSC) Chr 1: 51.24 – 51.27 Mb Chr 4: 109.31 – 109.34 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).^[7]

See also

• RING finger domain

Interactions

RNF11 has been shown to interact with RIPK1^[8] and STAMBP.^[9]