STAMBP

STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.^[4][5]

STAMBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZE, 3RZU, 3RZV
Identifiers
Aliases	STAMBP, AMSH, MICCAP, STAM binding protein
External IDs	OMIM: 606247; MGI: 1917777; HomoloGene: 4719; GeneCards: STAMBP; OMA:STAMBP - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 C3 Start 83,520,193 bp[1] End 83,549,711 bp[1]
Gene ontology Molecular function protein domain specific binding metal ion binding peptidase activity protein binding thiol-dependent deubiquitinase hydrolase activity metallopeptidase activity Lys63-specific deubiquitinase activity Cellular component endosome membrane plasma membrane nucleoplasm early endosome cleavage furrow extracellular exosome nucleus cytoplasm cytosol Biological process negative regulation of neuron apoptotic process receptor signaling pathway via JAK-STAT mitotic cytokinesis proteolysis negative regulation of Ras protein signal transduction negative regulation of phosphatidylinositol 3-kinase signaling positive regulation of cell population proliferation protein deubiquitination protein K63-linked deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10617 70527 Ensembl ENSG00000124356 ENSMUSG00000006906 UniProt O95630 Q9CQ26 RefSeq (mRNA) NM_006463 NM_201647 NM_213622 NM_024239 NM_001362078 NM_001362079 NM_001362080 RefSeq (protein) NP_006454 NP_964010 NP_998787 NP_001340896 NP_001340897 NP_001340898 NP_001340899 NP_001340900 NP_001340901 NP_001340902 NP_001340903 NP_001340904 NP_001340905 NP_077201 NP_001349007 NP_001349008 NP_001349009 Location (UCSC) n/a Chr 6: 83.52 – 83.55 Mb PubMed search [2] [3]
Wikidata
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Function

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.^[5]

Mutations in this gene have been associated to cases of microcephaly (doi:10.1038/ng.2602)

Interactions

STAMBP has been shown to interact with RNF11,^[6] Signal transducing adaptor molecule^[4][7] and GRAP2.^[8][9]