RNF4

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.^[5][6]

RNF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EA6, 2XEU, 4PPE
Identifiers
Aliases	RNF4, SLX5, SNURF, RES4-26, ring finger protein 4
External IDs	OMIM: 602850; MGI: 1201691; HomoloGene: 37711; GeneCards: RNF4; OMA:RNF4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,462,220 bp[1] End 2,625,320 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,493,633 bp[2] End 34,512,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus oocyte middle temporal gyrus epithelium of colon tonsil secondary oocyte bone marrow cells lymph node beta cell stromal cell of endometrium Top expressed in seminiferous tubule zygote lactiferous gland cumulus cell Ileal epithelium secondary oocyte ankle joint yolk sac spermatid epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding ubiquitin protein ligase activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding ubiquitin-protein transferase activity protein binding androgen receptor binding identical protein binding nucleosome binding transferase activity transcription factor binding SUMO polymer binding zinc ion binding nuclear receptor coactivator activity Cellular component cytoplasm PML body nucleoplasm nucleus Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated protein K63-linked ubiquitination response to arsenic-containing substance transcription, DNA-templated positive regulation of transcription, DNA-templated protein K11-linked ubiquitination regulation of kinetochore assembly protein K48-linked ubiquitination protein K6-linked ubiquitination protein ubiquitination regulation of spindle assembly positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6047 19822 Ensembl ENSG00000063978 ENSMUSG00000029110 UniProt P78317 Q9QZS2 RefSeq (mRNA) NM_002938 NM_001185009 NM_001185010 NM_011278 NM_001304269 NM_001304270 RefSeq (protein) NP_001171938 NP_001171939 NP_002929 NP_001291198 NP_001291199 NP_035408 Location (UCSC) Chr 4: 2.46 – 2.63 Mb Chr 5: 34.49 – 34.51 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.^[6]

Interactions

RNF4 has been shown to interact with TCF20,^[7] PATZ1^[8][9] and Androgen receptor.^[9][10][11] RNF4 has been shown to be responsible for the degradation of the Werner syndrome helicase in MSI-H cells after WRN inhibition.^[12]

See also

• RING finger domain