TCF20

Transcription factor 20 is a protein that in humans is encoded by the TCF20 gene.^[5][6][7]

TCF20
Identifiers
Aliases	TCF20, AR1, SPBP, TCF-20, transcription factor 20 (AR1), transcription factor 20, DDVIBA
External IDs	OMIM: 603107; MGI: 108399; HomoloGene: 4131; GeneCards: TCF20; OMA:TCF20 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2|22q13.3 Start 42,160,013 bp[1] End 42,343,616 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 82,692,637 bp[2] End 82,872,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence bone marrow cells islet of Langerhans tonsil mucosa of esophagus blood granulocyte lymph node olfactory zone of nasal mucosa superior frontal gyrus Top expressed in Rostral migratory stream genital tubercle tail of embryo dentate gyrus of hippocampal formation granule cell secondary oocyte olfactory tubercle ciliary body dorsal striatum conjunctival fornix supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity metal ion binding RNA binding DNA-binding transcription factor activity protein binding Cellular component nucleoplasm nuclear body nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6942 21411 Ensembl ENSG00000283681 ENSG00000281897 ENSG00000262024 ENSG00000282892 ENSG00000283026 ENSG00000280467 ENSG00000100207 ENSG00000276461 ENSMUSG00000041852 UniProt Q9UGU0 Q9EPQ8 RefSeq (mRNA) NM_005650 NM_181492 NM_001378418 NM_001114140 NM_013836 RefSeq (protein) NP_005641 NP_852469 NP_001365347 NP_001107612 NP_038864 NP_001389767 Location (UCSC) Chr 22: 42.16 – 42.34 Mb Chr 15: 82.69 – 82.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.^[7]

Interactions

TCF20 has been shown to interact with RNF4.^[8]