RNF41

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.^[5]

RNF41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FZP, 2GWF
Identifiers
Aliases	RNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDs	MGI: 1914838; HomoloGene: 4226; GeneCards: RNF41; OMA:RNF41 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,202,179 bp[1] End 56,221,933 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 76.55 cM Start 128,247,526 bp[2] End 128,277,310 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 paraflocculus of cerebellum frontal pole islet of Langerhans monocyte lateral nuclear group of thalamus stromal cell of endometrium gallbladder right coronary artery popliteal artery Top expressed in seminiferous tubule dentate gyrus of hippocampal formation granule cell primary visual cortex spermatid superior frontal gyrus ventricular zone granulocyte ganglionic eminence Rostral migratory stream cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-3 receptor binding erythropoietin receptor binding zinc ion binding metal ion binding protein binding transferase activity ubiquitin-protein transferase activity protein domain specific binding receptor tyrosine kinase binding ubiquitin protein ligase activity Cellular component cytosol perinuclear region of cytoplasm endoplasmic reticulum tubular network Biological process regulation of MAPK cascade extrinsic apoptotic signaling pathway positive regulation of DNA-binding transcription factor activity protein polyubiquitination regulation of reactive oxygen species metabolic process autophagy negative regulation of cell migration regulation of lymphocyte differentiation positive regulation of reactive oxygen species metabolic process protein ubiquitination regulation of protein kinase B signaling regulation of gene expression proteasomal protein catabolic process regulation of myeloid cell differentiation regulation of establishment of cell polarity negative regulation of cell population proliferation protein autoubiquitination apoptotic process negative regulation of mitophagy positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10193 67588 Ensembl ENSG00000181852 ENSMUSG00000025373 UniProt Q9H4P4 Q8BH75 RefSeq (mRNA) NM_001242826 NM_005785 NM_194358 NM_194359 NM_001164237 NM_026259 RefSeq (protein) NP_001229755 NP_005776 NP_919339 NP_919340 NP_001157709 NP_080535 Location (UCSC) Chr 12: 56.2 – 56.22 Mb Chr 10: 128.25 – 128.28 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[5]

Interactions

RNF41 has been shown to interact with USP8.^[6]

See also

• RING finger domain