USP8

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.^[5][6][7]

USP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WHB, 2A9U, 2GFO, 2GWF, 3N3K
Identifiers
Aliases	USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDs	OMIM: 603158; MGI: 1934029; HomoloGene: 3782; GeneCards: USP8; OMA:USP8 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 50,424,380 bp[1] End 50,514,421 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 126,549,248 bp[2] End 126,601,217 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve epithelium of colon ventricular zone testicle rectum monocyte caput epididymis corpus epididymis gallbladder Top expressed in spermatid seminiferous tubule spermatocyte tail of embryo genital tubercle right kidney stroma of bone marrow zygote deep cerebellar nuclei medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function cysteine-type peptidase activity SH3 domain binding thiol-dependent deubiquitinase peptidase activity protein binding cysteine-type endopeptidase activity hydrolase activity cadherin binding Cellular component cytoplasm endosome membrane plasma membrane extrinsic component of endosome membrane midbody endosome membrane extrinsic component of plasma membrane nucleus postsynaptic density dendritic spine early endosome cytosol glutamatergic synapse Biological process protein K48-linked deubiquitination ubiquitin-dependent protein catabolic process mitotic cytokinesis endosome organization proteolysis protein K63-linked deubiquitination cell cycle cell population proliferation protein deubiquitination cellular response to dexamethasone stimulus cellular response to nerve growth factor stimulus positive regulation of canonical Wnt signaling pathway Ras protein signal transduction regulation of protein stability regulation of protein localization regulation of protein catabolic process at postsynapse, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9101 84092 Ensembl ENSG00000138592 ENSMUSG00000027363 UniProt P40818 Q80U87 RefSeq (mRNA) NM_001128610 NM_001128611 NM_001283049 NM_005154 NM_001252580 NM_019729 RefSeq (protein) NP_001122082 NP_001269978 NP_005145 NP_001239509 NP_062703 Location (UCSC) Chr 15: 50.42 – 50.51 Mb Chr 2: 126.55 – 126.6 Mb PubMed search [3] [4]
Wikidata
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Interactions

USP8 has been shown to interact with RNF41^[8] and STAM2.^[9][10]

Diseases

In a few cases of Morbus Cushing's disease, a mutation of USP8 has been found.