RNF7

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.^[5][6][7]

RNF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ECL
Identifiers
Aliases	RNF7, CKBBP1, ROC2, SAG, ring finger protein 7, rbx2
External IDs	OMIM: 603863; MGI: 1337096; HomoloGene: 84476; GeneCards: RNF7; OMA:RNF7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 141,738,249 bp[1] End 141,747,560 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 96,352,990 bp[2] End 96,360,728 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland left adrenal cortex right adrenal gland right adrenal cortex right testis muscle layer of sigmoid colon left testis anterior pituitary body of pancreas muscle of thigh Top expressed in Epithelium of choroid plexus ureter morula morula iris median eminence gastrula supraoptic nucleus epithelium of lens vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding zinc ion binding copper ion binding cullin family protein binding metal ion binding NEDD8 transferase activity ubiquitin protein ligase activity Cellular component nucleoplasm nucleus Cul5-RING ubiquitin ligase complex cytoplasm cytosol Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex nuclear SCF ubiquitin ligase complex Cul4-RING E3 ubiquitin ligase complex cullin-RING ubiquitin ligase complex Biological process response to redox state protein ubiquitination protein neddylation post-translational protein modification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9616 19823 Ensembl ENSG00000114125 ENSMUSG00000051234 UniProt Q9UBF6 Q9WTZ1 RefSeq (mRNA) NM_001201370 NM_014245 NM_183063 NM_183237 NM_011279 NM_001311135 RefSeq (protein) NP_001188299 NP_055060 NP_899060 NP_001298064 NP_035409 Location (UCSC) Chr 3: 141.74 – 141.75 Mb Chr 9: 96.35 – 96.36 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27^Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

Interactions

RNF7 has been shown to interact with CSNK2B.^[8]

See also

• RING finger domain