RNPS1

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.^[5][6][7]

RNPS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4A8X
Identifiers
Aliases	RNPS1, E5.1, RNA binding protein with serine rich domain 1
External IDs	OMIM: 606447; MGI: 97960; HomoloGene: 40648; GeneCards: RNPS1; OMA:RNPS1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,253,116 bp[1] End 2,268,397 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,633,539 bp[2] End 24,644,875 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad cerebellar hemisphere right hemisphere of cerebellum right frontal lobe ganglionic eminence paraflocculus of cerebellum anterior cingulate cortex ventricular zone gastrocnemius muscle Brodmann area 10 Top expressed in tail of embryo genital tubercle ventricular zone embryo zygote yolk sac embryo neural layer of retina morula lip More reference expression data BioGPS n/a
Gene ontology Molecular function mRNA 3'-UTR binding protein binding RNA binding nucleic acid binding Cellular component cytoplasm cytosol nuclear speck exon-exon junction complex nucleoplasm ASAP complex nucleus Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus transcription, DNA-templated negative regulation of mRNA splicing, via spliceosome RNA splicing positive regulation of apoptotic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA 3'-end processing RNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10921 19826 Ensembl ENSG00000205937 ENSMUSG00000034681 UniProt Q15287 Q99M28 RefSeq (mRNA) NM_001286625 NM_001286626 NM_001286627 NM_006711 NM_080594 NM_001080127 NM_001080128 NM_009070 NM_001357626 RefSeq (protein) NP_001273554 NP_001273555 NP_001273556 NP_006702 NP_542161 NP_001073596 NP_001073597 NP_033096 NP_001344555 Location (UCSC) Chr 16: 2.25 – 2.27 Mb Chr 17: 24.63 – 24.64 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.^[7]

Interactions

RNPS1 has been shown to interact with SART3^[8] and Pinin.^[9][10]