SART3

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.^[5][6][7]

SART3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ
Identifiers
Aliases	SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein
External IDs	OMIM: 611684; MGI: 1858230; HomoloGene: 40977; GeneCards: SART3; OMA:SART3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 108,522,214 bp[1] End 108,561,400 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 113,880,507 bp[2] End 113,910,571 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte tendon of biceps brachii sural nerve Achilles tendon nipple internal globus pallidus cerebellar hemisphere cerebellar vermis epithelium of colon Top expressed in tail of embryo zygote neural layer of retina oocyte primary oocyte secondary oocyte genital tubercle epiblast ventricular zone lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U6atac snRNA binding histone binding U4 snRNA binding protein binding nucleic acid binding ubiquitin-specific protease binding U6 snRNA binding RNA binding Cellular component cytoplasm Cajal body nuclear speck U4/U6 x U5 tri-snRNP complex nucleoplasm U4/U6 snRNP U6atac snRNP U4atac/U6atac snRNP nucleus ASAP complex Biological process mRNA splicing, via spliceosome nucleosome assembly RNA processing spliceosomal tri-snRNP complex assembly homeostasis of number of cells positive regulation of histone deubiquitination hematopoietic stem cell proliferation mRNA processing spliceosomal snRNP assembly cell morphogenesis RNA splicing regulation of gene expression regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9733 53890 Ensembl ENSG00000075856 ENSMUSG00000018974 UniProt Q15020 Q9JLI8 RefSeq (mRNA) NM_014706 NM_016926 NM_001356621 NM_001356623 RefSeq (protein) NP_055521 NP_058622 NP_001343550 NP_001343552 Location (UCSC) Chr 12: 108.52 – 108.56 Mb Chr 5: 113.88 – 113.91 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.^[7]

Interactions

SART3 has been shown to interact with RNPS1^[8] and Androgen receptor.^[9]