Replication protein A3

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.^[5][6]

RPA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L1O, 1QUQ, 2PI2, 2PQA, 2Z6K, 3KDF
Identifiers
Aliases	RPA3, REPA3, RP-A p14, replication protein A3
External IDs	OMIM: 179837; MGI: 1915490; HomoloGene: 68285; GeneCards: RPA3; OMA:RPA3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p21.3 Start 7,636,518 bp[1] End 7,718,607 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 8,255,936 bp[2] End 8,259,173 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell beta cell trabecular bone embryo ventricular zone bone marrow olfactory zone of nasal mucosa nasal epithelium ganglionic eminence mucosa of transverse colon Top expressed in medial ganglionic eminence otic placode zygote yolk sac thymus dermis mandibular prominence maxillary prominence embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding DNA binding damaged DNA binding protein binding Cellular component nucleus nucleoplasm DNA replication factor A complex site of double-strand break Biological process DNA recombination translesion synthesis DNA replication nucleotide-excision repair, DNA gap filling transcription-coupled nucleotide-excision repair regulation of cell population proliferation nucleotide-excision repair, DNA incision error-free translesion synthesis cellular response to DNA damage stimulus regulation of mitotic cell cycle regulation of cellular response to heat interstrand cross-link repair error-prone translesion synthesis nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair DNA repair base-excision repair double-strand break repair via homologous recombination nucleotide-excision repair, preincision complex assembly telomere maintenance telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle DNA mismatch repair nucleotide-excision repair, DNA incision, 3'-to lesion regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6119 68240 Ensembl ENSG00000106399 ENSMUSG00000012483 UniProt P35244 Q9CQ71 RefSeq (mRNA) NM_002947 NM_026632 RefSeq (protein) NP_002938 NP_080908 Location (UCSC) Chr 7: 7.64 – 7.72 Mb Chr 6: 8.26 – 8.26 Mb PubMed search [3] [4]
Wikidata
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Interactions

RPA3 has been shown to interact with replication protein A1^[7][8] and replication protein A2.^[7][8]

See also

• Single-stranded binding protein
• Replication protein A
• Replication protein A1
• Replication protein A2