Replication protein A2

Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.^[5][6]

RPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DPU, 1L1O, 1QUQ, 1Z1D, 2PI2, 2PQA, 2Z6K, 3KDF, 4MQV, 4OU0
Identifiers
Aliases	RPA2, REPA2, RP-A p32, RP-A p34, RPA32, replication protein A2
External IDs	OMIM: 179836; MGI: 1339939; HomoloGene: 37712; GeneCards: RPA2; OMA:RPA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,891,524 bp[1] End 27,914,746 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,495,643 bp[2] End 132,506,063 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone granulocyte ganglionic eminence right testis left testis gastrocnemius muscle Achilles tendon right uterine tube gonad tibialis anterior muscle Top expressed in somite fetal liver hematopoietic progenitor cell primitive streak embryo ventricular zone mandibular prominence endocardial cushion abdominal wall germ layer ectoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein N-terminus binding single-stranded DNA binding damaged DNA binding protein binding enzyme binding protein phosphatase binding ubiquitin protein ligase binding G-rich strand telomeric DNA binding double-stranded DNA binding sequence-specific DNA binding Cellular component site of double-strand break PML body nucleoplasm telomere DNA replication factor A complex chromatin nucleus nuclear body condensed nuclear chromosome Biological process nucleotide-excision repair, DNA gap filling DNA recombination interstrand cross-link repair regulation of double-strand break repair via homologous recombination error-free translesion synthesis G1 phase error-prone translesion synthesis cellular response to DNA damage stimulus DNA replication mitotic G1 DNA damage checkpoint signaling regulation of DNA damage checkpoint regulation of cellular response to heat DNA mismatch repair translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision base-excision repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization regulation of signal transduction by p53 class mediator DNA repair double-strand break repair via homologous recombination nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA incision, 3'-to lesion protein localization to chromosome telomere maintenance telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle telomere maintenance via recombination DNA topological change DNA unwinding involved in DNA replication mitotic recombination telomere maintenance via telomerase reciprocal meiotic recombination heteroduplex formation positive regulation of helicase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6118 19891 Ensembl ENSG00000117748 ENSMUSG00000028884 UniProt P15927 Q62193 RefSeq (mRNA) NM_001286076 NM_001297558 NM_002946 NM_001355128 NM_001355129 NM_011284 RefSeq (protein) NP_001273005 NP_001284487 NP_002937 NP_001342057 NP_001342058 n/a Location (UCSC) Chr 1: 27.89 – 27.91 Mb Chr 4: 132.5 – 132.51 Mb PubMed search [3] [4]
Wikidata
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Interactions

RPA2 has been shown to interact with:

• Cyclin O,^[7]
• DNA-PKcs,^[8]
• Ku70,^[8]
• MEN1,^[9]
• RPA3,^[10][11]
• Replication protein A1,^[8][10]
• STAT3,^[12]
• TP53BP1^[13] and
• Uracil-DNA glycosylase.^[14]

See also

• Single-stranded binding protein
• Replication protein A
• Replication protein A1
• Replication protein A3