Replication protein A1

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.^[5]

RPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EWI, 1FGU, 1JMC, 1L1O, 2B29, 2B3G, 4IJH, 4IJL, 4IPC, 4IPD, 4IPG, 4IPH, 4LUO, 4LUV, 4LUZ, 4LW1, 4LWC, 4NB3, 4O0A, 4R4C, 4R4I, 4R4O, 4R4Q, 4R4T, 5E7N, 5EAY
Identifiers
Aliases	RPA1, HSSB, MST075, REPA1, RF-A, RP-A, RPA70, Replication protein A1, PFBMFT6
External IDs	OMIM: 179835; MGI: 1915525; HomoloGene: 2208; GeneCards: RPA1; OMA:RPA1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,829,702 bp[1] End 1,900,082 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.79 cM Start 75,188,992 bp[2] End 75,239,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone ganglionic eminence parietal pleura visceral pleura germinal epithelium gingival epithelium trabecular bone tibia parotid gland Top expressed in fetal liver hematopoietic progenitor cell retinal pigment epithelium ciliary body primitive streak vestibular membrane of cochlear duct iris Epithelium of choroid plexus abdominal wall endothelial cell of lymphatic vessel Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding single-stranded DNA binding damaged DNA binding protein binding nucleic acid binding G-rich strand telomeric DNA binding single-stranded telomeric DNA binding sequence-specific DNA binding Cellular component PML body nucleoplasm DNA replication factor A complex nucleus site of DNA damage Biological process DNA-dependent DNA replication nucleotide-excision repair, DNA gap filling DNA recombination interstrand cross-link repair error-free translesion synthesis G1 phase error-prone translesion synthesis cellular response to DNA damage stimulus DNA replication regulation of cellular response to heat DNA mismatch repair translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair DNA repair base-excision repair regulation of signal transduction by p53 class mediator double-strand break repair via homologous recombination nucleotide-excision repair, preincision complex assembly protein localization to chromosome telomere maintenance telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle DNA unwinding involved in DNA replication telomere maintenance via telomerase meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6117 68275 Ensembl ENSG00000132383 ENSMUSG00000000751 UniProt P27694 Q8VEE4 RefSeq (mRNA) NM_002945 NM_001355120 NM_001355121 NM_001164223 NM_026653 RefSeq (protein) NP_002936 NP_001342049 NP_001342050 NP_001157695 NP_080929 Location (UCSC) Chr 17: 1.83 – 1.9 Mb Chr 11: 75.19 – 75.24 Mb PubMed search [3] [4]
Wikidata
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Interactions

Replication protein A1 has been shown to interact with:

• BRCA2,^[6]
• BLM,^[7][8][9]
• MCM2,^[10]
• MCM4,^[10]
• MCM6,^[10]
• MCM7,^[10]
• MUTYH,^[11]
• ORC2L,^[10]
• ORC6L,^[10]
• P53,^[12][13]
• RPA2,^[14][15]
• RPA3,^[15][16]
• TIPIN,^[17]
• TP53BP1,^[18] and
• XPA.^[19]

See also

• DNA-binding subunit
• Replication protein A
• Replication protein A2
• Replication protein A3
• Single-stranded binding protein