RPS6KA2

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.^[5][6]

RPS6KA2
Identifiers
Aliases	RPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2
External IDs	OMIM: 601685; MGI: 1342290; HomoloGene: 100680; GeneCards: RPS6KA2; OMA:RPS6KA2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 166,409,364 bp[1] End 166,906,451 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 4.7 cM Start 7,437,514 bp[2] End 7,570,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus lower lobe of lung internal globus pallidus dorsal motor nucleus of vagus nerve inferior ganglion of vagus nerve C1 segment optic nerve right lung corpus callosum superior vestibular nucleus Top expressed in granulocyte muscle of thigh neural layer of retina tail of embryo superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex genital tubercle lens ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding protein binding protein serine/threonine/tyrosine kinase activity ATP binding magnesium ion binding kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity Cellular component cytoplasm cytosol nucleoplasm nucleus Biological process phosphorylation negative regulation of cell cycle protein phosphorylation positive regulation of apoptotic process negative regulation of cell population proliferation signal transduction intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6196 20112 Ensembl ENSG00000071242 ENSMUSG00000023809 UniProt Q15349 Q9WUT3 RefSeq (mRNA) NM_001006932 NM_021135 NM_001318936 NM_001318937 NM_001318938 NM_011299 RefSeq (protein) NP_001006933 NP_001305865 NP_001305866 NP_001305867 NP_066958 NP_035429 Location (UCSC) Chr 6: 166.41 – 166.91 Mb Chr 17: 7.44 – 7.57 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

RPS6KA2 has been shown to interact with MAPK3^[7][8] and MAPK1.^[7][8]