RPS6KA4

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.^[5][6][7]

RPS6KA4
Identifiers
Aliases	RPS6KA4, MSK2, RSK-B, S6K-alpha-4, ribosomal protein S6 kinase A4
External IDs	OMIM: 603606; MGI: 1930076; HomoloGene: 69288; GeneCards: RPS6KA4; OMA:RPS6KA4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,359,148 bp[1] End 64,372,215 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,806,578 bp[2] End 6,818,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte monocyte right frontal lobe apex of heart right coronary artery mucosa of transverse colon cingulate gyrus prefrontal cortex anterior cingulate cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity protein binding ATP binding magnesium ion binding Cellular component nucleoplasm nucleus cytoplasm cytosol Biological process intracellular signal transduction regulation of transcription, DNA-templated phosphorylation positive regulation of histone acetylation interleukin-1-mediated signaling pathway protein phosphorylation positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity inflammatory response negative regulation of cytokine production positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8986 56613 Ensembl ENSG00000162302 ENSMUSG00000118668 UniProt O75676 Q9Z2B9 RefSeq (mRNA) NM_001006944 NM_001300802 NM_003942 NM_001318361 NM_019924 RefSeq (protein) NP_001006945 NP_001287731 NP_001305290 NP_003933 NP_064308 Location (UCSC) Chr 11: 64.36 – 64.37 Mb Chr 19: 6.81 – 6.82 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[7]

Interactions

RPS6KA4 has been shown to interact with MAPK14.^[5]