RS134-49

RS134-49
Identifiers
	IUPAC name 4-methyl-3-(1,2,3,6-tetrahydropyridin-5-yl)-1H-indole;
CAS Number	2945139-94-4 ;
PubChem CID	168941768;
Chemical and physical data
Formula	C14H16N2
Molar mass	212.296 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C2C(=CC=C1)NC=C2C3=CCCNC3;
	InChI InChI=1S/C14H16N2/c1-10-4-2-6-13-14(10)12(9-16-13)11-5-3-7-15-8-11/h2,4-6,9,15-16H,3,7-8H2,1H3; Key:UIZDBLDTIJHWHC-UHFFFAOYSA-N;

RS134-49 is a tetrahydropyridinylindole derivative related to psychedelic tryptamines which acts as a 5-HT_2A receptor agonist, with a 5-HT_2A K_i of 11.5nM and an EC₅₀ of 22nM. It is a biased agonist selective for activation of the G_q coupled signalling pathway with weaker activation of the β-arrestin 2 coupled pathway, but shows a more balanced profile than related compounds such as (R)-69.^[1]^[2]

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