RUVBL2

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

RUVBL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQA, 2XSZ, 3UK6
Identifiers
Aliases	RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
External IDs	OMIM: 604788; MGI: 1342299; HomoloGene: 4856; GeneCards: RUVBL2; OMA:RUVBL2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,993,562 bp[1] End 49,015,970 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,071,184 bp[2] End 45,087,520 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa mucosa of paranasal sinus ventricular zone parotid gland tendon of biceps brachii embryo Top expressed in epiblast somite tail of embryo embryo mandibular prominence embryo primitive streak maxillary prominence morula ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleotide binding 5'-3' DNA helicase activity helicase activity unfolded protein binding DNA helicase activity ATPase activity protein binding identical protein binding chromatin DNA binding ATP binding hydrolase activity RNA polymerase II core promoter sequence-specific DNA binding TFIID-class transcription factor complex binding protein homodimerization activity ADP binding ATPase binding Cellular component membrane nuclear matrix NuA4 histone acetyltransferase complex intracellular anatomical structure nucleoplasm MLL1 complex extracellular exosome nucleus Swr1 complex R2TP complex cytoplasm centrosome cytosol Ino80 complex Biological process chromatin remodeling DNA recombination regulation of transcription, DNA-templated cellular response to UV histone H2A acetylation cellular response to estradiol stimulus transcription, DNA-templated positive regulation of histone acetylation cellular response to DNA damage stimulus establishment of protein localization to chromatin protein folding positive regulation of telomerase RNA localization to Cajal body histone H4 acetylation regulation of growth DNA repair positive regulation of transcription by RNA polymerase II DNA duplex unwinding box C/D snoRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10856 20174 Ensembl ENSG00000183207 ENSMUSG00000003868 UniProt Q9Y230 Q9WTM5 RefSeq (mRNA) NM_006666 NM_001321190 NM_001321191 NM_011304 RefSeq (protein) NP_001308119 NP_001308120 NP_006657 NP_035434 Location (UCSC) Chr 19: 48.99 – 49.02 Mb Chr 7: 45.07 – 45.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.^[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.^[6]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1^[7] and Activating transcription factor 2.^[8]