RuvB-like 1

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.^[5] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.^[6] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.

RUVBL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C9O, 2XSZ
Identifiers
Aliases	RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1
External IDs	OMIM: 603449; MGI: 1928760; HomoloGene: 37839; GeneCards: RUVBL1; OMA:RUVBL1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 128,064,778 bp[1] End 128,153,914 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 88,442,391 bp[2] End 88,474,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ventricular zone gonad olfactory zone of nasal mucosa ganglionic eminence islet of Langerhans stromal cell of endometrium right testis left testis placenta Top expressed in epiblast tail of embryo embryo embryo lens ventricular zone neural tube ganglionic eminence yolk sac blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding 5'-3' DNA helicase activity helicase activity DNA helicase activity ATPase activity protein binding hydrolase activity ATP binding cadherin binding TFIID-class transcription factor complex binding ADP binding ATPase binding Cellular component membrane nuclear matrix NuA4 histone acetyltransferase complex nucleoplasm microtubule organizing center MLL1 complex extracellular exosome cytoskeleton nucleus Swr1 complex R2TP complex cytoplasm cytosol Ino80 complex Biological process DNA recombination regulation of transcription, DNA-templated positive regulation of protein targeting to mitochondrion histone H2A acetylation regulation of transcription by RNA polymerase II CENP-A containing chromatin assembly transcription, DNA-templated cellular response to DNA damage stimulus cell division regulation of autophagy of mitochondrion spermatogenesis positive regulation of telomerase RNA localization to Cajal body histone H4 acetylation cell cycle regulation of growth beta-catenin-TCF complex assembly DNA duplex unwinding protein deubiquitination DNA repair box C/D snoRNP assembly chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8607 56505 Ensembl ENSG00000175792 ENSG00000284901 ENSMUSG00000030079 UniProt Q9Y265 P60122 RefSeq (mRNA) NM_003707 NM_001319084 NM_001319086 NM_019685 RefSeq (protein) NP_001306013 NP_001306015 NP_003698 NP_062659 Location (UCSC) Chr 3: 128.06 – 128.15 Mb Chr 6: 88.44 – 88.47 Mb PubMed search [3] [4]
Wikidata
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Interactions

RuvB-like 1 has been shown to interact with:

• ACTL6A,^[7]
• Beta-catenin,^[8]
• EP400,^[9]
• Myc,^[7][9] and
• RUVBL2.^[10]