Retinoid X receptor gamma

Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.^[5][6]

RXRG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GL8
Identifiers
Aliases	RXRG, NR2B3, RXRC, Retinoid X receptor gamma, RXR-gamma, RXRgamma
External IDs	OMIM: 180247; MGI: 98216; HomoloGene: 21373; GeneCards: RXRG; OMA:RXRG - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 165,400,922 bp[1] End 165,445,355 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 74.99 cM Start 167,425,953 bp[2] End 167,467,192 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh anterior pituitary gastrocnemius muscle caudate nucleus putamen nucleus accumbens testicle C1 segment islet of Langerhans tibial nerve Top expressed in lumbar spinal ganglion muscle of thigh triceps brachii muscle temporal muscle quadriceps femoris muscle vastus lateralis muscle sternocleidomastoid muscle myocardium of ventricle striatum of neuraxis superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA binding metal ion binding sequence-specific DNA binding steroid hormone receptor activity protein binding nuclear receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process retinoic acid receptor signaling pathway regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein homotetramerization positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus transcription, DNA-templated steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6258 20183 Ensembl ENSG00000143171 ENSMUSG00000015843 UniProt P48443 P28705 RefSeq (mRNA) NM_001256570 NM_001256571 NM_006917 NM_001159731 NM_009107 RefSeq (protein) NP_001243499 NP_001243500 NP_008848 NP_001153203 NP_033133 Location (UCSC) Chr 1: 165.4 – 165.45 Mb Chr 1: 167.43 – 167.47 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

See also

• Retinoid X receptor

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.^[7]