S100A3

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.^[5][6]

S100A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KSO, 3NSI, 3NSK, 3NSL, 3NSO
Identifiers
Aliases	S100A3, S100E, S100 calcium binding protein A3
External IDs	OMIM: 176992; MGI: 1338849; HomoloGene: 2223; GeneCards: S100A3; OMA:S100A3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,547,329 bp[1] End 153,549,258 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.26 cM Start 90,491,966 bp[2] End 90,510,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg skin of abdomen ectocervix upper lobe of left lung canal of the cervix right coronary artery vagina decidua Descending thoracic aorta Top expressed in lip hair follicle corneal stroma embryo morula granulocyte conjunctival fornix skin of back embryo skin of abdomen More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 6274 20197 Ensembl ENSG00000188015 ENSMUSG00000001021 UniProt P33764 P62818 RefSeq (mRNA) NM_002960 NM_011310 NM_001355597 NM_001355600 NM_001355602 RefSeq (protein) NP_002951 NP_035440 NP_001342526 NP_001342529 NP_001342531 Location (UCSC) Chr 1: 153.55 – 153.55 Mb Chr 3: 90.49 – 90.51 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.^[6]