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S100A6

Human protein and coding gene From Wikipedia, the free encyclopedia

S100A6
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S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.[5]

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Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.[5]

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Interactions

S100A6 has been shown to interact with S100B[6][7] and SUGT1.[8]

Pathology

S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.[9]

References

Further reading

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