S100A6

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.^[5]

S100A6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K8U, 1K96, 1K9K, 1K9P, 2M1K, 4YBH
Identifiers
Aliases	S100A6, 2A9, 5B10, CABP, CACY, PRA, S100 calcium binding protein A6, S10A6
External IDs	OMIM: 114110; MGI: 1339467; HomoloGene: 7925; GeneCards: S100A6; OMA:S100A6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,534,599 bp[1] End 153,536,244 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.35 cM Start 90,520,189 bp[2] End 90,531,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of transverse colon ascending aorta upper lobe of left lung Descending thoracic aorta right coronary artery left coronary artery right lung olfactory zone of nasal mucosa tibial nerve Top expressed in corneal stroma transitional epithelium of urinary bladder left colon decidua gastrula granulocyte endothelial cell of lymphatic vessel umbilical cord mucous cell of stomach skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding S100 protein binding protein homodimerization activity ion transmembrane transporter activity zinc ion binding metal ion binding calcium-dependent protein binding protein binding tropomyosin binding Cellular component cytoplasm cytosol nuclear envelope membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane perinuclear region of cytoplasm extracellular exosome nucleus extracellular region collagen-containing extracellular matrix Biological process axonogenesis positive regulation of fibroblast proliferation ion transmembrane transport signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6277 20200 Ensembl ENSG00000197956 ENSMUSG00000001025 UniProt P06703 P14069 RefSeq (mRNA) NM_014624 NM_011313 RefSeq (protein) NP_055439 NP_035443 Location (UCSC) Chr 1: 153.53 – 153.54 Mb Chr 3: 90.52 – 90.53 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.^[5]

Interactions

S100A6 has been shown to interact with S100B^[6][7] and SUGT1.^[8]

Pathology

S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.^[9]