SUGT1

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.^[5][6]

SUGT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RL1
Identifiers
Aliases	SUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
External IDs	OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 52,652,709 bp[1] End 52,700,909 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 79,825,131 bp[2] End 79,872,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium pancreatic epithelial cell myocardium of left ventricle oocyte cartilage tissue parietal pleura tibia pancreatic ductal cell gingival epithelium tendon of biceps brachii Top expressed in morula morula blastocyst otic vesicle medial ganglionic eminence abdominal wall epiblast superior surface of tongue otic placode spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol nucleus kinetochore ubiquitin ligase complex protein-containing complex Biological process regulation of protein stability mitotic cell cycle protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10910 67955 Ensembl ENSG00000165416 ENSMUSG00000022024 UniProt Q9Y2Z0 Q9CX34 RefSeq (mRNA) NM_001130912 NM_006704 NM_001320831 NM_026474 RefSeq (protein) NP_001124384 NP_001307760 NP_006695 NP_080750 Location (UCSC) Chr 13: 52.65 – 52.7 Mb Chr 14: 79.83 – 79.87 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.^[6]

Interactions

SUGT1 has been shown to interact with S100A6.^[7]