SAP130

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.^[5][6][7]

SAP130
Identifiers
Aliases	SAP130, Sin3A associated protein 130
External IDs	OMIM: 609697; MGI: 1919782; HomoloGene: 11577; GeneCards: SAP130; OMA:SAP130 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,941,217 bp[1] End 128,028,120 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 31,767,424 bp[2] End 31,856,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis secondary oocyte testicle ventricular zone ganglionic eminence stromal cell of endometrium gonad popliteal artery Top expressed in zygote tail of embryo genital tubercle secondary oocyte primary oocyte hand yolk sac otic vesicle otolith organ supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity histone acetyltransferase activity Cellular component nucleus Sin3-type complex nuclear speck Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79595 269003 Ensembl ENSG00000136715 ENSMUSG00000024260 UniProt Q9H0E3 Q8BIH0 RefSeq (mRNA) NM_001145928 NM_024545 NM_001330299 NM_001330300 NM_001330301 NM_001330302 NM_001330303 NM_172965 NM_001357554 NM_001357555 RefSeq (protein) NP_001139400 NP_001317228 NP_001317229 NP_001317230 NP_001317231 NP_001317232 NP_078821 NP_766553 NP_001344483 NP_001344484 Location (UCSC) Chr 2: 127.94 – 128.03 Mb Chr 18: 31.77 – 31.86 Mb PubMed search [3] [4]
Wikidata
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Function

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]^[7]

Interactions

SAP130 has been shown to interact with:

• CSN1S1,^[8]
• CUL2,^[8]
• Myc,^[9]
• SIN3A,^[6] and
• Von Hippel–Lindau tumor suppressor^[8] and