CUL2

Cullin-2 is a protein that in humans is encoded by the CUL2 gene.^[5][6]

CUL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WQO
Identifiers
Aliases	CUL2, cullin 2
External IDs	OMIM: 603135; MGI: 1918995; HomoloGene: 2662; GeneCards: CUL2; OMA:CUL2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.21 Start 35,008,504 bp[1] End 35,127,006 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 3,382,988 bp[2] End 3,436,377 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm muscle of thigh gastrocnemius muscle gonad Achilles tendon ventricular zone stromal cell of endometrium islet of Langerhans ganglionic eminence biceps brachii Top expressed in superior cervical ganglion epiblast abdominal wall facial motor nucleus arcuate nucleus ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus sternocleidomastoid muscle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase activity ubiquitin protein ligase binding protein-containing complex binding Cellular component cullin-RING ubiquitin ligase complex cytosol nucleolus VCB complex nucleoplasm Cul2-RING ubiquitin ligase complex SCF ubiquitin ligase complex Biological process intrinsic apoptotic signaling pathway viral process protein catabolic process regulation of transcription from RNA polymerase II promoter in response to hypoxia negative regulation of cell population proliferation ubiquitin-dependent protein catabolic process post-translational protein modification G1/S transition of mitotic cell cycle protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8453 71745 Ensembl ENSG00000108094 ENSMUSG00000024231 UniProt Q13617 Q9D4H8 RefSeq (mRNA) NM_001198777 NM_001198778 NM_001198779 NM_003591 NM_001324375 NM_001324376 NM_029402 NM_001360829 RefSeq (protein) NP_001185706 NP_001185707 NP_001185708 NP_001311304 NP_001311305 NP_003582 NP_083678 NP_001347758 Location (UCSC) Chr 10: 35.01 – 35.13 Mb Chr 18: 3.38 – 3.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CUL2 has been shown to interact with:

• CAND1,^[7][8]
• DCUN1D1,^[9]
• RBX1,^[10][11]
• SAP130,^[7]
• TCEB2^[7][12] and
• Von Hippel-Lindau tumor suppressor.^{[7][12][13][14][15]}