SCYE1

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene.^[5][6][7]

AIMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E7Z, 1EUJ, 1FL0, 4R3Z
Identifiers
Aliases	AIMP1, EMAP2, EMAPII, HLD3, SCYE1, p43, aminoacyl tRNA synthetase complex interacting multifunctional protein 1
External IDs	OMIM: 603605; MGI: 102774; HomoloGene: 31260; GeneCards: AIMP1; OMA:AIMP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 106,315,544 bp[1] End 106,349,456 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 132,366,242 bp[2] End 132,390,131 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon rectum thoracic diaphragm endometrium monocyte gastrocnemius muscle islet of Langerhans cartilage tissue beta cell Descending thoracic aorta Top expressed in somite maxillary prominence mandibular prominence primitive streak epiblast hair follicle plantaris muscle renal corpuscle extensor digitorum longus muscle medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding RNA binding GTPase binding tRNA binding cytokine activity Cellular component Golgi apparatus membrane aminoacyl-tRNA synthetase multienzyme complex transport vesicle extracellular region cell surface endoplasmic reticulum cytoplasmic vesicle nucleus methionyl glutamyl tRNA synthetase complex extracellular space cytoplasm cytosol Biological process blood vessel morphogenesis protein biosynthesis cell-cell signaling negative regulation of endothelial cell proliferation chemotaxis cell adhesion defense response to virus response to wounding angiogenesis glucose metabolic process leukocyte migration signal transduction apoptotic process tRNA aminoacylation for protein translation inflammatory response carbohydrate metabolic process regulation of signaling receptor activity positive regulation of glucagon secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9255 13722 Ensembl ENSG00000164022 ENSMUSG00000028029 UniProt Q12904 P31230 RefSeq (mRNA) NM_004757 NM_001142415 NM_001142416 NM_007926 NM_001368626 RefSeq (protein) NP_001135887 NP_001135888 NP_004748 NP_001355555 NP_031952 Location (UCSC) Chr 4: 106.32 – 106.35 Mb Chr 3: 132.37 – 132.39 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multiaminoacyl-tRNA synthetase complex (mARS). Pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.^[7] As an inflammatory cytokine, AIMp1/p43 has demonstrated the ability to skew T-helper polarization in the direction of Th-1, and its homozygous deletion leads to a hyper-polarized Th-2 phenotype.

Interactions

SCYE1 has been shown to interact with SMURF2.^[8]