SMURF2

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.^[5][6]

SMURF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZVD, 2DJY, 2JQZ, 2KXQ, 2LTZ
Identifiers
Aliases	SMURF2, SMAD specific E3 ubiquitin protein ligase 2
External IDs	OMIM: 605532; MGI: 1913563; HomoloGene: 41490; GeneCards: SMURF2; OMA:SMURF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3-q24.1 Start 64,542,282 bp[1] End 64,662,307 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 106,710,892 bp[2] End 106,811,541 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell secondary oocyte amniotic fluid pylorus saphenous vein lactiferous duct visceral pleura pericardium caput epididymis Achilles tendon Top expressed in hand otolith organ utricle secondary oocyte zygote left lung lobe right lung lobe endothelial cell of lymphatic vessel genital tubercle superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity transforming growth factor beta receptor binding SMAD binding Cellular component cytosol membrane ubiquitin ligase complex plasma membrane nucleoplasm membrane raft nuclear speck nucleus cytoplasm Biological process positive regulation of canonical Wnt signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway BMP signaling pathway positive regulation of trophoblast cell migration ubiquitin-dependent SMAD protein catabolic process regulation of transforming growth factor beta receptor signaling pathway protein ubiquitination negative regulation of transcription, DNA-templated protein polyubiquitination Wnt signaling pathway, planar cell polarity pathway protein deubiquitination ubiquitin-dependent protein catabolic process negative regulation of BMP signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64750 66313 Ensembl ENSG00000108854 ENSMUSG00000018363 UniProt Q9HAU4 A2A5Z6 RefSeq (mRNA) NM_022739 NM_025481 NM_001362894 RefSeq (protein) NP_073576 NP_079757 NP_001349823 Location (UCSC) Chr 17: 64.54 – 64.66 Mb Chr 11: 106.71 – 106.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SMURF2 has been shown to interact with:

• Mothers against decapentaplegic homolog 1,^[5]
• Mothers against decapentaplegic homolog 2,^[5][7][8]
• Mothers against decapentaplegic homolog 3,^[5][7][8]
• Mothers against decapentaplegic homolog 7,^[9][10][11]
• SCYE1,^[11]
• SMURF1,^[12] and
• Ubiquitin C.^[11][13]

• TOP2A,^[14]