SEMA4D

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.^[5]

SEMA4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OLZ, 3OL2
Identifiers
Aliases	SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18
External IDs	OMIM: 601866; MGI: 109244; HomoloGene: 21282; GeneCards: SEMA4D; OMA:SEMA4D - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.2 Start 89,360,787 bp[1] End 89,498,130 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,685,529 bp[2] End 51,793,747 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment granulocyte corpus callosum blood monocyte inferior ganglion of vagus nerve lymph node muscle of thigh internal globus pallidus substantia nigra Top expressed in granulocyte muscle of thigh mesenteric lymph nodes thymus lumbar subsegment of spinal cord cumulus cell tibiofemoral joint blood dentate gyrus of hippocampal formation granule cell spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding transmembrane signaling receptor activity protein binding semaphorin receptor binding neuropilin binding identical protein binding signaling receptor activity chemorepellent activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane extracellular space Biological process regulation of dendrite morphogenesis negative regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase signaling multicellular organism development leukocyte aggregation nervous system development negative regulation of cell adhesion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis regulation of cell projection organization negative regulation of osteoblast differentiation positive regulation of collateral sprouting regulation of cell shape negative regulation of peptidyl-tyrosine phosphorylation cell differentiation positive regulation of protein phosphorylation semaphorin-plexin signaling pathway cell adhesion immune response ossification involved in bone maturation positive regulation of cell migration negative regulation of transcription by RNA polymerase II positive regulation of GTPase activity negative regulation of alkaline phosphatase activity negative chemotaxis neural crest cell migration negative regulation of axon extension involved in axon guidance positive regulation of inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10507 20354 Ensembl ENSG00000187764 ENSMUSG00000021451 UniProt Q92854 O09126 RefSeq (mRNA) NM_001142287 NM_006378 NM_182635 NM_001371194 NM_001371195 NM_001371196 NM_001371197 NM_001371198 NM_001371199 NM_001371200 NM_001371201 NM_001371202 NM_001281880 NM_013660 RefSeq (protein) NP_001135759 NP_006369 NP_001358123 NP_001358124 NP_001358125 NP_001358126 NP_001358127 NP_001358128 NP_001358129 NP_001358130 NP_001358131 NP_001268809 NP_038688 NP_001365242 NP_001365243 NP_001365246 NP_001365247 NP_001365248 NP_001365249 NP_001365251 NP_001365252 NP_001365253 NP_001365244 NP_001365245 NP_001365250 NP_001365254 Location (UCSC) Chr 9: 89.36 – 89.5 Mb Chr 13: 51.69 – 51.79 Mb PubMed search [3] [4]
Wikidata
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Function

Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.^[6]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.^[7][8]

During skin damage repairs, SEMA4D interacts with Plexin B2 on Gamma delta T cells to play a role in the healing process.^[9]

See also

• Cluster of differentiation