SENP6

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.^[5]

SENP6
Identifiers
Aliases	SENP6, SSP1, SUSP1, SUMO1/sentrin specific peptidase 6, SUMO specific peptidase 6
External IDs	OMIM: 605003; MGI: 1922075; HomoloGene: 9196; GeneCards: SENP6; OMA:SENP6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 75,601,509 bp[1] End 75,718,281 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E1 Start 80,066,903 bp[2] End 80,144,953 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone gastric mucosa right uterine tube sural nerve left ovary ganglionic eminence right ovary body of uterus left lobe of thyroid gland Top expressed in genital tubercle tail of embryo ventricular zone zygote granulocyte ganglionic eminence gastric mucosa left lung lobe mucous cell of stomach epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity protein binding hydrolase activity SUMO-specific endopeptidase activity Cellular component nucleus nucleoplasm cytosol cytoplasm Biological process protein desumoylation protein modification by small protein removal regulation of spindle assembly protein sumoylation proteolysis regulation of kinetochore assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26054 215351 Ensembl ENSG00000112701 ENSMUSG00000034252 UniProt Q9GZR1 Q6P7W0 RefSeq (mRNA) NM_001100409 NM_001304792 NM_015571 NM_146003 NM_001311110 RefSeq (protein) NP_001093879 NP_001291721 NP_056386 NP_001298039 NP_666115 Location (UCSC) Chr 6: 75.6 – 75.72 Mb Chr 9: 80.07 – 80.14 Mb PubMed search [3] [4]
Wikidata
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Function

Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

See also

• small ubiquitin-related modifier 1