SEPT7

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.^[5][6]

SEPTIN7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QAG, 3T5D, 3TW4
Identifiers
Aliases	SEPTIN7, CDC10, CDC3, NBLA02942, SEPT7A, septin 7, SEPT7
External IDs	OMIM: 603151; MGI: 1335094; HomoloGene: 1354; GeneCards: SEPTIN7; OMA:SEPTIN7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.2 Start 35,800,932 bp[1] End 35,907,110 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 25,163,735 bp[2] End 25,219,867 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum subthalamic nucleus inferior ganglion of vagus nerve external globus pallidus occipital lobe ventricular zone prefrontal cortex primary visual cortex Achilles tendon endothelial cell Top expressed in atrioventricular valve dermis prefrontal cortex Gonadal ridge left lung lobe calvaria optic nerve nucleus accumbens deep cerebellar nuclei umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding structural molecule activity protein binding identical protein binding cadherin binding GTPase activity molecular adaptor activity Cellular component cytosol cell projection spindle cilium septin complex stress fiber chromosome midbody apical plasma membrane axoneme cleavage furrow chromosome, centromeric region cytoskeleton extracellular exosome nucleus kinetochore cytoplasm sperm annulus non-motile cilium septin ring microtubule cytoskeleton motile cilium Biological process cilium assembly protein heterooligomerization cytokinesis regulation of embryonic cell shape cell division positive regulation of non-motile cilium assembly cell cycle spermatogenesis cell differentiation negative regulation of cell migration positive regulation of apoptotic process cytoskeleton-dependent cytokinesis negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 989 235072 Ensembl ENSG00000122545 ENSMUSG00000001833 UniProt Q16181 O55131 RefSeq (mRNA) NM_001011553 NM_001242956 NM_001788 NM_001363715 NM_001375299 NM_001205367 NM_009859 NM_001359736 NM_001359737 NM_001359738 RefSeq (protein) NP_001011553 NP_001229885 NP_001779 NP_001350644 NP_001362228 NP_001192296 NP_033989 NP_001346665 NP_001346666 NP_001346667 Location (UCSC) Chr 7: 35.8 – 35.91 Mb Chr 9: 25.16 – 25.22 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

Interactions

SEPT7 has been shown to interact with SEPT2^[7][8] and SEPT9.^[8]