SEPT2

Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.^[4][5]

SEPTIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QA5, 2QAG, 2QNR
Identifiers
Aliases	SEPTIN2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5, septin 2, SEPT2
External IDs	OMIM: 601506; MGI: 97298; HomoloGene: 3243; GeneCards: SEPTIN2; OMA:SEPTIN2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,315,100 bp[1] End 241,354,027 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone optic nerve germinal epithelium secondary oocyte parietal pleura corpus callosum visceral pleura endometrium external globus pallidus Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding cadherin binding identical protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cell projection membrane plasma membrane spindle septin complex chromosome photoreceptor connecting cilium cell cortex exocyst midbody nucleolus ciliary membrane actin cytoskeleton perinuclear region of cytoplasm axoneme cleavage furrow chromosome, centromeric region cytoskeleton extracellular exosome nucleus kinetochore cytosol sperm annulus non-motile cilium cilium septin ring microtubule cytoskeleton motile cilium Biological process cell division cell cycle neuron projection development spermatogenesis cell differentiation smoothened signaling pathway cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4735 18000 Ensembl ENSG00000168385 n/a UniProt Q15019 P42208 RefSeq (mRNA) NM_001008491 NM_001008492 NM_001282972 NM_001282973 NM_004404 NM_006155 NM_001321029 NM_001321030 NM_001321031 NM_001321032 NM_001321033 NM_001321034 NM_001321035 NM_001349287 NM_001349288 NM_001349289 NM_001349290 NM_001349291 NM_001349302 NM_001349304 NM_001349305 NM_001349306 NM_001349307 NM_001349308 NM_001349309 NM_001349310 NM_001349311 NM_001349312 NM_001349313 NM_001349314 NM_001349315 NM_001159717 NM_001159718 NM_001159719 NM_010891 RefSeq (protein) NP_001008491 NP_001008492 NP_001269901 NP_001269902 NP_001307958 NP_001307959 NP_001307960 NP_001307961 NP_001307962 NP_001307963 NP_001307964 NP_004395 NP_006146 NP_001336216 NP_001336217 NP_001336218 NP_001336219 NP_001336220 NP_001336231 NP_001336233 NP_001336234 NP_001336235 NP_001336236 NP_001336237 NP_001336238 NP_001336239 NP_001336240 NP_001336241 NP_001336242 NP_001336243 NP_001336244 NP_001153189 NP_001153190 NP_001153191 NP_035021 Location (UCSC) Chr 2: 241.32 – 241.35 Mb n/a PubMed search [2] [3]
Wikidata
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Function

SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments.^[6] SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain.^[6] Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. Septins, SOCS7, and NCK1 are part of a signaling pathway that ties regulation of the DNA damage response to the cytoskeleton.^[7]

Interactions

SEPT2 has been shown to interact with:

• SEPT6^[8][9]
• SEPT7,^[8][10] and
• SEPT9.^[8]