SEPT8

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.^[5][6][7]

SEPTIN8
Identifiers
Aliases	SEPTIN8, SEP2, septin 8, SEPT8
External IDs	OMIM: 608418; MGI: 894310; HomoloGene: 57205; GeneCards: SEPTIN8; OMA:SEPTIN8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 132,750,819 bp[1] End 132,807,241 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.96 cM Start 53,410,084 bp[2] End 53,440,392 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobe Top expressed in facial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton septin ring microtubule cytoskeleton septin complex septin filament array presynapse membrane cell junction axon synaptic vesicle membrane cytoplasmic vesicle cell projection synapse Biological process mitotic cytokinesis septin ring assembly cilium assembly regulation of SNARE complex assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23176 20362 Ensembl ENSG00000164402 ENSMUSG00000018398 UniProt Q92599 Q8CHH9 RefSeq (mRNA) NM_001098811 NM_001098812 NM_001098813 NM_001300798 NM_001300799 NM_015146 NM_001252332 NM_001252333 NM_033144 NM_001347496 NM_001361968 NM_001361969 RefSeq (protein) NP_001092281 NP_001092282 NP_001092283 NP_001287727 NP_001287728 NP_055961 NP_001239261 NP_001239262 NP_001334425 NP_149156 NP_001348897 NP_001348898 Location (UCSC) Chr 5: 132.75 – 132.81 Mb Chr 11: 53.41 – 53.44 Mb PubMed search [3] [4]
Wikidata
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Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.^[7]

Interactions

SEPT8 has been shown to interact with PFTK1^[8] and SEPT5.^[9][10]