SF3A3

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.^[5][6][7]

SF3A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DT7
Identifiers
Aliases	SF3A3, PRP9, PRPF9, SAP61, SF3a60, splicing factor 3a subunit 3
External IDs	OMIM: 605596; MGI: 1922312; HomoloGene: 4949; GeneCards: SF3A3; OMA:SF3A3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,956,975 bp[1] End 37,990,075 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 124,608,569 bp[2] End 124,626,253 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon epithelium of colon ganglionic eminence ventricular zone monocyte rectum gastrocnemius muscle islet of Langerhans stromal cell of endometrium Top expressed in otic placode saccule otic vesicle primitive streak tail of embryo abdominal wall epiblast embryo primary oocyte mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding nucleic acid binding RNA binding Cellular component nuclear speck catalytic step 2 spliceosome spliceosomal complex nucleus nucleoplasm U2 snRNP U2-type precatalytic spliceosome Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing mRNA 3'-splice site recognition RNA splicing U2-type prespliceosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10946 75062 Ensembl ENSG00000183431 ENSMUSG00000028902 UniProt Q12874 Q9D554 RefSeq (mRNA) NM_006802 NM_001320830 NM_029157 RefSeq (protein) NP_001307759 NP_006793 NP_083433 Location (UCSC) Chr 1: 37.96 – 37.99 Mb Chr 4: 124.61 – 124.63 Mb PubMed search [3] [4]
Wikidata
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This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.^[7]

Interactions

SF3A3 has been shown to interact with SF3A1.^[6][8]