SF3A1

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.^[5][6]

SF3A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKH, 2DT6, 2DT7
Identifiers
Aliases	SF3A1, PRP21, PRPF21, SAP114, SF3A120, splicing factor 3a subunit 1
External IDs	OMIM: 605595; MGI: 1914715; HomoloGene: 4294; GeneCards: SF3A1; OMA:SF3A1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,331,988 bp[1] End 30,356,919 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 4,110,350 bp[2] End 4,132,541 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm sural nerve stromal cell of endometrium ganglionic eminence ventricular zone epithelium of colon bone marrow cells left ovary left testis right testis Top expressed in epiblast yolk sac otic vesicle tail of embryo ventricular zone genital tubercle saccule somite neural layer of retina zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex U2-type spliceosomal complex U2-type prespliceosome nucleus nucleoplasm nuclear speck U2 snRNP U2-type precatalytic spliceosome Biological process mRNA splicing, via spliceosome mRNA processing RNA processing mRNA 3'-splice site recognition RNA splicing regulation of alternative mRNA splicing, via spliceosome U2-type prespliceosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10291 67465 Ensembl ENSG00000099995 ENSMUSG00000002129 UniProt Q15459 Q8K4Z5 RefSeq (mRNA) NM_005877 NM_001005409 NM_026175 RefSeq (protein) NP_005868 NP_080451 Location (UCSC) Chr 22: 30.33 – 30.36 Mb Chr 11: 4.11 – 4.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

Interactions

SF3A1 has been shown to interact with SF3A3^[7][8] and CDC5L.^[9]