SF3B2

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.^[5][6]

SF3B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO5
Identifiers
Aliases	SF3B2, Cus1, SAP145, SF3B145, SF3b1, SF3b150, splicing factor 3b subunit 2, CFM
External IDs	OMIM: 605591; MGI: 2441856; HomoloGene: 6678; GeneCards: SF3B2; OMA:SF3B2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,050,729 bp[1] End 66,069,308 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,323,960 bp[2] End 5,345,483 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone left testis right testis anterior pituitary right uterine tube ganglionic eminence right lobe of thyroid gland left lobe of thyroid gland right hemisphere of cerebellum body of uterus Top expressed in Rostral migratory stream external carotid artery internal carotid artery supraoptic nucleus condyle conjunctival fornix fossa substantia nigra motor neuron primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex U2-type spliceosomal complex U12-type spliceosomal complex precatalytic spliceosome nucleus U2 snRNP nucleoplasm nuclear speck U2-type precatalytic spliceosome Biological process mRNA splicing, via spliceosome mRNA processing viral process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10992 319322 Ensembl ENSG00000087365 ENSMUSG00000024853 UniProt Q13435 Q3UJB0 RefSeq (mRNA) NM_006842 NM_030109 NM_001362454 RefSeq (protein) NP_006833 NP_084385 NP_001349383 Location (UCSC) Chr 11: 66.05 – 66.07 Mb Chr 19: 5.32 – 5.35 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.^[6]

Interactions

SF3B2 has been shown to interact with SF3B4,^[7][8] RBM7,^[9] SF3B1^[10][11] and CDC5L.^[12]