SFPQ

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.^[5][6]

SFPQ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WII, 4WIJ, 4WIK
Identifiers
Aliases	SFPQ, POMP100, PPP1R140, PSF, splicing factor proline and glutamine rich
External IDs	OMIM: 605199; MGI: 1918764; HomoloGene: 3714; GeneCards: SFPQ; OMA:SFPQ - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,176,378 bp[1] End 35,193,446 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 61.2 cM Start 127,021,324 bp[2] End 127,037,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone ganglionic eminence right uterine tube sural nerve cerebellar hemisphere right hemisphere of cerebellum left ovary right ovary sperm Top expressed in tail of embryo genital tubercle ventricular zone mandibular prominence Rostral migratory stream maxillary prominence epiblast abdominal wall ganglionic eminence neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding histone deacetylase binding chromatin binding transcription cis-regulatory region binding protein binding nucleic acid binding DNA binding protein homodimerization activity RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding Cellular component cytoplasm paraspeckles nuclear matrix RNA polymerase II transcription regulator complex chromatin nucleus nucleoplasm extracellular matrix nuclear speck dendrite cytoplasm Biological process histone H3 deacetylation DNA recombination regulation of transcription, DNA-templated rhythmic process negative regulation of circadian rhythm mRNA processing negative regulation of transcription by RNA polymerase II chromosome organization transcription, DNA-templated cellular response to DNA damage stimulus regulation of cell cycle regulation of circadian rhythm double-strand break repair via homologous recombination RNA splicing positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of sister chromatid cohesion negative regulation of transcription, DNA-templated alternative mRNA splicing, via spliceosome DNA repair positive regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response dendritic transport of messenger ribonucleoprotein complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6421 71514 Ensembl ENSG00000116560 ENSMUSG00000028820 UniProt P23246 Q8VIJ6 RefSeq (mRNA) NM_005066 NM_023603 RefSeq (protein) NP_005057 NP_076092 Location (UCSC) Chr 1: 35.18 – 35.19 Mb Chr 4: 127.02 – 127.04 Mb PubMed search [3] [4]
Wikidata
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Interactions

SFPQ has been shown to interact with PTBP1,^[5][7] NONO,^[8] CDC5L^[9] and Ubiquitin C.^[10]