SH3GL3

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.^[5][6]

SH3GL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EW3, 2Z0V
Identifiers
Aliases	SH3GL3, CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13, SH3 domain containing GRB2 like endophilin A3, SH3 domain containing GRB2 like 3, endophilin A3
External IDs	OMIM: 603362; MGI: 700011; HomoloGene: 37723; GeneCards: SH3GL3; OMA:SH3GL3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.2 Start 83,447,228 bp[1] End 83,618,743 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D3|7 47.15 cM Start 82,173,840 bp[2] End 82,307,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm middle frontal gyrus corpus callosum C1 segment Brodmann area 10 Brodmann area 46 hippocampus proper Region I of hippocampus proper left testis substantia nigra Top expressed in spermatocyte spermatid superior cervical ganglion seminiferous tubule nucleus accumbens optic nerve barrel cortex ventromedial nucleus motor neuron olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding lipid binding protein C-terminus binding Cellular component cytoplasm endosome early endosome early endosome membrane membrane acrosomal vesicle synapse presynapse postsynaptic endosome glutamatergic synapse postsynaptic density, intracellular component Biological process central nervous system development endocytosis signal transduction positive regulation of neuron differentiation negative regulation of clathrin-dependent endocytosis regulation of clathrin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6457 20408 Ensembl ENSG00000140600 ENSMUSG00000030638 UniProt Q99963 Q62421 RefSeq (mRNA) NM_001301108 NM_001301109 NM_003027 NM_001324182 NM_001324183 NM_001324184 NM_001324185 NM_001324186 NM_001324187 NM_001277954 NM_001277955 NM_017400 RefSeq (protein) NP_001288037 NP_001288038 NP_001311111 NP_001311112 NP_001311113 NP_001311114 NP_001311115 NP_001311116 NP_003018 NP_001264883 NP_001264884 NP_059096 Location (UCSC) Chr 15: 83.45 – 83.62 Mb Chr 7: 82.17 – 82.31 Mb PubMed search [3] [4]
Wikidata
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Interactions

SH3GL3 has been shown to interact with Huntingtin^[7] and SH3KBP1.^[8]