SH3KBP1

SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85^[5], in rodents - Ruk^[6]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.^[7][8]

SH3KBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N64
Identifiers
Aliases	SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDs	OMIM: 300374; MGI: 1889583; HomoloGene: 10971; GeneCards: SH3KBP1; OMA:SH3KBP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.12 Start 19,533,977 bp[1] End 19,887,600 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 158,410,268 bp[2] End 158,761,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte myocardium of left ventricle mucosa of ileum lateral nuclear group of thalamus skin of arm cardiac muscle tissue of right atrium inferior ganglion of vagus nerve subthalamic nucleus blood white blood cell Top expressed in thymus zygote myocardium of ventricle right ventricle granulocyte cardiac muscles atrioventricular valve secondary oocyte stroma of bone marrow extraocular muscle More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding protein binding Cellular component cytosol membrane cell-cell junction focal adhesion plasma membrane endocytic vesicle synapse cell junction neuron projection cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle cytoplasm Biological process negative regulation of epidermal growth factor receptor signaling pathway endocytosis cell-cell signaling cytoskeleton organization regulation of cell shape cell migration apoptotic process membrane organization axon guidance actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30011 58194 Ensembl ENSG00000147010 ENSMUSG00000040990 UniProt Q96B97 Q5JPT2 Q8R550 RefSeq (mRNA) NM_001024666 NM_001184960 NM_031892 NM_001353890 NM_001353891 NM_001353892 NM_001353893 NM_001353894 NM_001353895 NM_001353897 NM_001135727 NM_001135728 NM_001290661 NM_001290664 NM_021389 NM_001374701 RefSeq (protein) NP_001019837 NP_001171889 NP_114098 NP_001340819 NP_001340820 NP_001340821 NP_001340822 NP_001340823 NP_001340824 NP_001340826 NP_001129199 NP_001129200 NP_001277590 NP_001277593 NP_067364 NP_001361630 Location (UCSC) Chr X: 19.53 – 19.89 Mb Chr X: 158.41 – 158.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]^[9]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,^[10] Grb2,^[11][12] SH3GLB2,^[13][14] SH3GL3,^[13] SH3GL2,^[14] BCAR1,^[10] Epidermal growth factor receptor,^[14][15] CBLB,^[15] Cbl gene,^{[10][12][13][14][15]} SOS1,^[10] CRK^[10] and PAK2.^[16]