SIAH2

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.^[5][6]

SIAH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5H9M
Identifiers
Aliases	SIAH2, hSiah2, siah E3 ubiquitin protein ligase 2
External IDs	OMIM: 602213; MGI: 108062; HomoloGene: 21053; GeneCards: SIAH2; OMA:SIAH2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 150,741,125 bp[1] End 150,763,477 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 D|3 28.68 cM Start 58,582,359 bp[2] End 58,599,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex monocyte ectocervix right lobe of liver blood canal of the cervix bone marrow stromal cell of endometrium Top expressed in secondary oocyte zygote primary oocyte seminiferous tubule spermatid olfactory epithelium ankle joint parotid gland right kidney islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function transcription corepressor activity zinc ion binding metal ion binding protein binding ubiquitin conjugating enzyme binding transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity Cellular component cytoplasm cytosol intracellular membrane-bounded organelle nucleoplasm soma early endosome neuron projection nucleus Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process small GTPase mediated signal transduction regulation of protein ubiquitination negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process axon guidance multicellular organism development protein ubiquitination cell cycle negative regulation of canonical Wnt signaling pathway apoptotic process negative regulation of nucleic acid-templated transcription protein polyubiquitination protein deubiquitination ubiquitin-dependent protein catabolic process negative regulation of netrin-activated signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of circadian rhythm rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6478 20439 Ensembl ENSG00000181788 ENSMUSG00000036432 UniProt O43255 Q06986 RefSeq (mRNA) NM_005067 NM_009174 RefSeq (protein) NP_005058 NP_033200 Location (UCSC) Chr 3: 150.74 – 150.76 Mb Chr 3: 58.58 – 58.6 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.^[6]

Interactions

SIAH2 has been shown to interact with PEG10,^[7] Synaptophysin,^[8] PEG3^[9] and VAV1.^[10]