VAV1

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.^[5]

VAV1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Identifiers
Aliases	VAV1, VAV, vav guanine nucleotide exchange factor 1
External IDs	OMIM: 164875; MGI: 98923; HomoloGene: 3961; GeneCards: VAV1; OMA:VAV1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 6,772,708 bp[1] End 6,857,366 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 D|17 29.76 cM Start 57,586,100 bp[2] End 57,635,031 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen bone marrow cells lymph node appendix palpebral conjunctiva epithelium of nasopharynx trabecular bone Top expressed in superior surface of tongue gallbladder granulocyte thymus mesenteric lymph nodes interventricular septum spleen blood gastrula lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity DNA-binding transcription factor activity metal ion binding protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphotyrosine residue binding Cellular component cytosol cell-cell junction plasma membrane Biological process regulation of cell size intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity T cell costimulation neutrophil chemotaxis reactive oxygen species metabolic process platelet activation Fc-epsilon receptor signaling pathway positive regulation of GTPase activity T cell differentiation vascular endothelial growth factor receptor signaling pathway immune response phagocytosis positive regulation of apoptotic process integrin-mediated signaling pathway regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction positive regulation of natural killer cell mediated cytotoxicity T cell activation positive regulation of cell adhesion regulation of transcription, DNA-templated phosphatidylinositol phosphate biosynthetic process small GTPase mediated signal transduction G protein-coupled receptor signaling pathway positive regulation of protein kinase B signaling cytokine-mediated signaling pathway positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7409 22324 Ensembl ENSG00000141968 ENSMUSG00000034116 UniProt P15498 P27870 RefSeq (mRNA) NM_001258206 NM_001258207 NM_005428 NM_001163815 NM_001163816 NM_011691 RefSeq (protein) NP_001245135 NP_001245136 NP_005419 NP_001157287 NP_001157288 NP_035821 Location (UCSC) Chr 19: 6.77 – 6.86 Mb Chr 17: 57.59 – 57.64 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.^[6]

Interactions

VAV1 has been shown to interact with:

• ARHGDIB,^[7]
• Abl gene,^[8]
• Cbl gene^[9][10]
• EZH2,^[11]
• Grb2,^{[12][13][14][15]}
• JAK2,^[16][17]
• Ku70,^[18]
• LAT,^[19][20]
• LCP2,^[21][22]
• MAPK1,^[13][15]
• PIK3R1,^[16][23]
• PLCG1,^[23]
• PRKCQ,^[24]
• S100B,^[25]
• SHB,^[26]
• SIAH2,^[12] and
• Syk.^[9][13][27]