SIK1

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.^[5][6]

SIK1
Identifiers
Aliases	SIK1, MSK, SIK, SNF1LK, EIEE30, salt inducible kinase 1, SIK-1, SIK1B, DEE30
External IDs	OMIM: 605705; MGI: 104754; HomoloGene: 136094; GeneCards: SIK1; OMA:SIK1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 43,414,483 bp[1] End 43,427,131 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.25 cM Start 32,063,224 bp[2] End 32,074,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa skin of abdomen skin of leg gallbladder bone marrow cell left ovary left uterine tube vagina right ovary upper lobe of left lung Top expressed in granulocyte decidua yolk sac lip muscle of thigh genital tubercle proximal tubule tail of embryo esophagus endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cAMP response element binding protein binding 14-3-3 protein binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding protein kinase binding magnesium ion binding Cellular component cytoplasm nucleus nucleotide-activated protein kinase complex Biological process regulation of myotube differentiation cell differentiation intracellular signal transduction phosphorylation regulation of sodium ion transport rhythmic process cardiac muscle cell differentiation negative regulation of triglyceride biosynthetic process negative regulation of CREB transcription factor activity multicellular organism development protein phosphorylation negative regulation of gluconeogenesis regulation of mitotic cell cycle regulation of cell differentiation protein autophosphorylation cell cycle positive regulation of anoikis entrainment of circadian clock by photoperiod cellular response to hormone stimulus negative regulation of TOR signaling cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150094 17691 Ensembl ENSG00000142178 ENSMUSG00000024042 UniProt P57059 Q60670 RefSeq (mRNA) NM_173354 NM_010831 RefSeq (protein) NP_001307572 NP_034961 Location (UCSC) Chr 21: 43.41 – 43.43 Mb Chr 17: 32.06 – 32.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Serine/threonine-protein kinase
• SIK2