SLAMF6

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.^[5][6]

SLAMF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF7
Identifiers
Aliases	SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDs	OMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2-q23.3 Start 160,485,030 bp[1] End 160,523,262 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.54 cM Start 171,745,082 bp[2] End 171,780,737 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node spleen appendix blood bone marrow cells superficial temporal artery gallbladder mucosa of transverse colon rectum Top expressed in thymus spleen lymph node blood mesenteric lymph nodes gastrula granulocyte submandibular gland subcutaneous adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane Biological process natural killer cell proliferation immune system process positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity adaptive immune response T-helper 17 cell lineage commitment regulation of immune response natural killer cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114836 30925 Ensembl ENSG00000162739 ENSMUSG00000015314 UniProt Q96DU3 Q9ET39 RefSeq (mRNA) NM_052931 NM_001184714 NM_001184715 NM_001184716 NM_030710 NM_001347186 NM_001347187 RefSeq (protein) NP_001171643 NP_001171644 NP_001171645 NP_443163 NP_001334115 NP_001334116 NP_109635 Location (UCSC) Chr 1: 160.49 – 160.52 Mb Chr 1: 171.75 – 171.78 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.^[6]