SLC26A8

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.^[5][6][7]

SLC26A8
Identifiers
Aliases	SLC26A8, SPGF3, TAT1, solute carrier family 26 member 8
External IDs	OMIM: 608480; MGI: 2385046; HomoloGene: 27095; GeneCards: SLC26A8; OMA:SLC26A8 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,943,516 bp[1] End 36,024,868 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.82 cM Start 28,856,757 bp[2] End 28,909,207 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis cerebellar hemisphere right hemisphere of cerebellum secondary oocyte sperm testicle blood bone marrow cells right frontal lobe Top expressed in spermatocyte spermatid seminiferous tubule neural layer of retina superior frontal gyrus primary visual cortex granulocyte embryo cerebellar cortex dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function anion transmembrane transporter activity sulfate transmembrane transporter activity secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity oxalate transmembrane transporter activity protein binding chloride channel activity chloride transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process flagellated sperm motility cell differentiation oxalate transport sulfate transport regulation of membrane potential regulation of intracellular pH ion transport anion transport multicellular organism development bicarbonate transport meiosis transmembrane transport spermatogenesis sperm capacitation chloride transport chloride transmembrane transport sulfate transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116369 224661 Ensembl ENSG00000112053 ENSMUSG00000036196 UniProt Q96RN1 Q8R0C3 RefSeq (mRNA) NM_001193476 NM_052961 NM_138718 NM_001290320 NM_146076 RefSeq (protein) NP_001180405 NP_443193 NP_619732 NP_001277249 Location (UCSC) Chr 6: 35.94 – 36.02 Mb Chr 17: 28.86 – 28.91 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.^[7]

Interactions

SLC26A8 has been shown to interact with RACGAP1.^[8]