SLITRK6

SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.^[5][6]

SLITRK6
Identifiers
Aliases	SLITRK6, DFNMYP, SLIT and NTRK like family member 6
External IDs	OMIM: 609681; MGI: 2443198; HomoloGene: 12986; GeneCards: SLITRK6; OMA:SLITRK6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.1 Start 85,792,790 bp[1] End 85,806,683 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E3 Start 110,986,012 bp[2] End 110,992,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell urethra mucosa of ileum nasal epithelium skin of arm urinary bladder trachea minor salivary glands mucosa of paranasal sinus jejunal mucosa Top expressed in otolith organ utricle vestibular sensory epithelium maxillary prominence medial dorsal nucleus islet of Langerhans otic vesicle skin of face genital tubercle migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 84189 239250 Ensembl ENSG00000184564 ENSMUSG00000045871 UniProt Q9H5Y7 Q8C110 RefSeq (mRNA) NM_032229 NM_175499 RefSeq (protein) NP_115605 NP_780708 Location (UCSC) Chr 13: 85.79 – 85.81 Mb Chr 14: 110.99 – 110.99 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.^[5][6]

Clinical significance

Mutations in SLITRK6 cause high myopia and deafness in humans and mice.^[7]

As a drug target

The protein is the target for the antibody-drug conjugate ASG-15ME which is in phase 1 clinical trials for urothelial cancer.^[8]