Small nuclear ribonucleoprotein D1

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.^[5][6]

SNRPD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B34, 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD1, HsT2456, SMD1, SNRPD, Sm-D1, Small nuclear ribonucleoprotein D1, small nuclear ribonucleoprotein D1 polypeptide
External IDs	OMIM: 601063; MGI: 98344; HomoloGene: 107532; GeneCards: SNRPD1; OMA:SNRPD1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 21,612,314 bp[1] End 21,633,524 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 10,617,775 bp[2] End 10,642,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone oocyte mucosa of sigmoid colon mucosa of pharynx oral cavity mucosa of transverse colon olfactory zone of nasal mucosa islet of Langerhans appendix Top expressed in somite epiblast mandibular prominence maxillary prominence embryo abdominal wall embryo medial ganglionic eminence ventricular zone hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding U1 snRNP binding RNA binding Cellular component cytoplasm SMN-Sm protein complex cytosol prespliceosome catalytic step 2 spliceosome spliceosomal tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex spliceosomal complex commitment complex U4 snRNP nucleus U1 snRNP U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome RNA processing mRNA processing spliceosomal complex assembly RNA splicing import into nucleus spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6632 20641 Ensembl ENSG00000167088 ENSMUSG00000002477 UniProt P62314 P62315 RefSeq (mRNA) NM_006938 NM_001291916 NM_009226 RefSeq (protein) NP_001278845 NP_008869 NP_033252 Location (UCSC) Chr 18: 21.61 – 21.63 Mb Chr 18: 10.62 – 10.64 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.^[7]

Interactions

Small nuclear ribonucleoprotein D1 has been shown to interact with:

• CDC5L,^[8]
• CLNS1A,^[9]
• DDX20,^[10]
• SMN1,^[11][12][13] and
• Small nuclear ribonucleoprotein D2^[14][15]