SNRPD3

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.^[5][6][7]

SNRPD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3B, 3CW1, 3PGW, 3VRI, 4PJO, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD3, SMD3, Sm-D3, small nuclear ribonucleoprotein D3 polypeptide
External IDs	OMIM: 601062; MGI: 1914582; HomoloGene: 3078; GeneCards: SNRPD3; OMA:SNRPD3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 24,555,958 bp[1] End 24,582,052 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 75,353,385 bp[2] End 75,373,215 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence islet of Langerhans ventricular zone white blood cell monocyte appendix muscle of thigh granulocyte olfactory zone of nasal mucosa duodenum Top expressed in abdominal wall otic placode ventricular zone somite migratory enteric neural crest cell mandibular prominence maxillary prominence endocardial cushion dermis hand More reference expression data BioGPS n/a
Gene ontology Molecular function histone pre-mRNA DCP binding U2 snRNA binding protein binding enzyme binding U7 snRNA binding telomerase RNA binding U1 snRNP binding RNA binding Cellular component SMN-Sm protein complex cytosol prespliceosome catalytic step 2 spliceosome spliceosomal tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome U7 snRNP precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex telomerase holoenzyme complex spliceosomal complex commitment complex U4 snRNP extracellular exosome nucleus U1 snRNP cytoplasm nuclear body U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription RNA processing mRNA processing spliceosomal complex assembly RNA splicing histone mRNA metabolic process protein methylation import into nucleus spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6634 67332 Ensembl ENSG00000100028 ENSMUSG00000020180 UniProt P62318 P62320 RefSeq (mRNA) NM_001278656 NM_004175 NM_026095 RefSeq (protein) NP_001265585 NP_004166 NP_080371 Location (UCSC) Chr 22: 24.56 – 24.58 Mb Chr 10: 75.35 – 75.37 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.^[7]

Interactions

SNRPD3 has been shown to interact with:

• CDC5L,^[8]
• CLNS1A,^[9]
• DDX20,^[10] and
• Protein arginine methyltransferase 5.^[9]