SNW1

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.^[5][6][7]

SNW1
Identifiers
Aliases	SNW1, Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP, SNW domain containing 1, SKIP1, FUN20
External IDs	OMIM: 603055; MGI: 1913604; HomoloGene: 56557; GeneCards: SNW1; OMA:SNW1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 77,717,599 bp[1] End 77,761,207 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D2 Start 87,495,845 bp[2] End 87,519,044 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx parotid gland Achilles tendon amniotic fluid parietal pleura tendon of biceps brachii germinal epithelium trabecular bone tibia vena cava Top expressed in renal corpuscle Epithelium of choroid plexus retinal pigment epithelium medullary collecting duct ureter motor neuron maxillary prominence primitive streak ventricular zone genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity transcription coactivator activity Notch binding protein binding retinoic acid receptor binding SMAD binding vitamin D receptor binding RNA binding enzyme binding androgen receptor binding Cellular component catalytic step 2 spliceosome nuclear matrix nucleoplasm cyclin/CDK positive transcription elongation factor complex spliceosomal complex nucleus nuclear body post-mRNA release spliceosomal complex nuclear speck U2-type catalytic step 2 spliceosome Biological process Notch signaling pathway cellular response to retinoic acid positive regulation of transforming growth factor beta receptor signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of transcription, DNA-templated positive regulation of mRNA splicing, via spliceosome regulation of retinoic acid receptor signaling pathway regulation of transcription by RNA polymerase II mRNA processing regulation of vitamin D receptor signaling pathway negative regulation of transcription by RNA polymerase II positive regulation of neurogenesis retinoic acid receptor signaling pathway positive regulation of histone H3-K4 methylation RNA splicing positive regulation of vitamin D receptor signaling pathway transcription initiation from RNA polymerase II promoter viral process negative regulation of transcription, DNA-templated positive regulation by host of viral transcription positive regulation of transcription by RNA polymerase II transcription, DNA-templated mRNA splicing, via spliceosome generation of catalytic spliceosome for second transesterification step positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22938 66354 Ensembl ENSG00000100603 ENSMUSG00000021039 UniProt Q13573 Q9CSN1 RefSeq (mRNA) NM_012245 NM_001318844 NM_025507 RefSeq (protein) NP_001305773 NP_036377 NP_079783 Location (UCSC) Chr 14: 77.72 – 77.76 Mb Chr 12: 87.5 – 87.52 Mb PubMed search [3] [4]
Wikidata
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Function

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.^[7]

Interactions

SNW1 has been shown to interact with:

• CIR,^[8]
• Calcitriol receptor,^[6][9]
• Histone deacetylase 2,^[8]
• Mothers against decapentaplegic homolog 2,^[10]
• Mothers against decapentaplegic homolog 3,^[10]
• NOTCH1^[11][12]
• Nuclear receptor co-repressor 2,^[8][11]
• Nuclear receptor coactivator 1,^[9]
• PABPN1,^[13]
• RBPJ,^[8][11]
• Retinoblastoma protein,^[14] and
• SKI protein.^[15][16][10]