RBPJ

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.^[5][6][7]

RBPJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8X, 3NBN, 3V79
Identifiers
Aliases	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
External IDs	OMIM: 147183; MGI: 96522; HomoloGene: 7511; GeneCards: RBPJ; OMA:RBPJ - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 26,163,455 bp[1] End 26,435,131 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 29.37 cM Start 53,623,494 bp[2] End 53,814,704 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus Achilles tendon nipple corpus callosum dorsal motor nucleus of vagus nerve middle temporal gyrus synovial joint inferior ganglion of vagus nerve pericardium visceral pleura Top expressed in vestibular membrane of cochlear duct stroma of bone marrow ventricular zone zygote renal corpuscle carotid body ciliary body Paneth cell medial ganglionic eminence ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding DNA strand exchange activity chromatin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor activity sequence-specific DNA binding transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleolus MAML1-RBP-Jkappa- ICN1 complex transcription regulator complex cytoplasm nucleus nucleoplasm transcription repressor complex Biological process artery morphogenesis regulation of transcription by RNA polymerase II neuron differentiation epidermal cell fate specification positive regulation of cell population proliferation club cell differentiation somatic stem cell population maintenance endocardium development cell fate commitment DNA recombination somitogenesis positive regulation of transcription from RNA polymerase II promoter in response to hypoxia defense response to bacterium regulation of timing of cell differentiation regulation of transcription, DNA-templated humoral immune response keratinocyte differentiation hair follicle maturation negative regulation of cell population proliferation pituitary gland development negative regulation of cell differentiation Notch signaling involved in heart development transcription, DNA-templated positive regulation of gene expression arterial endothelial cell fate commitment myeloid dendritic cell differentiation blood vessel remodeling secondary heart field specification regulation of cell population proliferation positive regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter sebaceous gland development positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment inflammatory response to antigenic stimulus heart development auditory receptor cell fate commitment B cell differentiation regulation of gene expression Notch signaling pathway dorsal aorta morphogenesis atrioventricular canal development positive regulation of ephrin receptor signaling pathway epithelial to mesenchymal transition involved in endocardial cushion formation outflow tract morphogenesis cardiac left ventricle morphogenesis negative regulation of transcription by RNA polymerase II labyrinthine layer blood vessel development blood vessel lumenization endocardium morphogenesis ventricular trabecula myocardium morphogenesis negative regulation of ossification positive regulation of cell proliferation involved in heart morphogenesis positive regulation of cardiac muscle cell proliferation angiogenesis epithelial to mesenchymal transition positive regulation of BMP signaling pathway positive regulation of ERBB signaling pathway blood vessel endothelial cell fate specification negative regulation of transcription, DNA-templated positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathway hemopoiesis aortic valve development pulmonary valve development ventricular septum morphogenesis negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3516 19664 Ensembl ENSG00000168214 ENSMUSG00000039191 UniProt Q06330 P31266 RefSeq (mRNA) NM_005349 NM_015874 NM_203283 NM_203284 NM_001363577 NM_001374400 NM_001374401 NM_001374402 NM_001374403 NM_001379406 NM_001379407 NM_001379408 NM_001379409 NM_001080927 NM_001080928 NM_001277116 NM_009035 NM_001359152 RefSeq (protein) NP_005340 NP_056958 NP_976028 NP_976029 NP_001350506 NP_001361329 NP_001361330 NP_001361331 NP_001361332 NP_001366335 NP_001366336 NP_001366337 NP_001366338 NP_001074396 NP_001074397 NP_001264045 NP_033061 NP_001346081 Location (UCSC) Chr 4: 26.16 – 26.44 Mb Chr 5: 53.62 – 53.81 Mb PubMed search [3] [4]
Wikidata
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RBPJ^[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.^[9]

Interactions

RBPJ has been shown to interact with:

• NOTCH1^[10][11]
• NCOR2,^[12][13]
• PCAF,^[14]
• SND1,^[15][16]
• SNW1,^[15][17]
• SOX18,^[18] and
• HIF1a. ^[19]