SNX2

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.^[5][6]

SNX2
Identifiers
Aliases	SNX2, TRG-9, sorting nexin 2
External IDs	OMIM: 605929; MGI: 1915054; HomoloGene: 2332; GeneCards: SNX2; OMA:SNX2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.2 Start 122,775,079 bp[1] End 122,834,543 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D1 Start 53,309,388 bp[2] End 53,353,937 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon islet of Langerhans ventricular zone gallbladder rectum ganglionic eminence Descending thoracic aorta popliteal artery tibial arteries Top expressed in blastocyst yolk sac spleen sciatic nerve placenta morula morula olfactory epithelium uterus stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding protein heterodimerization activity transferrin receptor binding lipid binding cadherin binding Cellular component cytoplasm cell projection early endosome membrane membrane retromer, tubulation complex retromer complex endosome membrane lamellipodium extrinsic component of membrane cytosol lysosome endosome protein-containing complex Biological process endocytosis vesicle organization early endosome to Golgi transport retrograde transport, endosome to Golgi protein complex oligomerization protein transport intracellular protein transport lamellipodium morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6643 67804 Ensembl ENSG00000205302 ENSMUSG00000034484 UniProt O60749 Q9CWK8 RefSeq (mRNA) NM_003100 NM_001278199 NM_026386 NM_001357463 RefSeq (protein) NP_001265128 NP_003091 NP_080662 NP_001344392 Location (UCSC) Chr 5: 122.78 – 122.83 Mb Chr 18: 53.31 – 53.35 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.^[6]

Interactions

SNX2 has been shown to interact with FNBP1.^[7][8]