FNBP1

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.^[5][6][7]

FNBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EFL
Identifiers
Aliases	FNBP1, FBP17, formin binding protein 1
External IDs	OMIM: 606191; MGI: 109606; HomoloGene: 100983; GeneCards: FNBP1; OMA:FNBP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,887,187 bp[1] End 130,043,194 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,916,218 bp[2] End 31,032,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum gastric mucosa cerebellar hemisphere saphenous vein right hemisphere of cerebellum inferior ganglion of vagus nerve paraflocculus of cerebellum thymus epithelium of colon sural nerve Top expressed in cerebellar cortex cerebellar vermis lobe of cerebellum pontine nuclei deep cerebellar nuclei ventral tegmental area medial geniculate nucleus lateral geniculate nucleus medial dorsal nucleus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding lipid binding Cellular component cytoplasm plasma membrane clathrin-coated pit lysosome cell cortex cytoskeleton membrane cytoplasmic vesicle cytosol Biological process endocytosis membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23048 14269 Ensembl ENSG00000187239 ENSMUSG00000075415 UniProt Q96RU3 Q80TY0 RefSeq (mRNA) NM_015033 NM_001363755 NM_001038700 NM_001177648 NM_001177649 NM_001177650 NM_019406 NM_001355105 NM_001355106 RefSeq (protein) NP_055848 NP_001350684 NP_001033789 NP_001171119 NP_001171120 NP_001171121 NP_062279 NP_001342034 NP_001342035 Location (UCSC) Chr 9: 129.89 – 130.04 Mb Chr 2: 30.92 – 31.03 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.^[7]

Interactions

FNBP1 has been shown to interact with:

• AKAP9,^[8]
• DNM1,^[9]
• Fas ligand^[10]
• SNX2,^[6][11] and
• TNKS.^[11]