SNX9

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.^[5][6][7]

SNX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE
Identifiers
Aliases	SNX9, SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDs	OMIM: 605952; MGI: 1913866; HomoloGene: 49454; GeneCards: SNX9; OMA:SNX9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 157,700,387 bp[1] End 157,945,077 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 3.51 cM Start 5,891,604 bp[2] End 5,982,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue mucosa of ileum superficial temporal artery Achilles tendon decidua right coronary artery tendon of biceps brachii tail of epididymis synovial membrane tibial arteries Top expressed in Ileal epithelium zygote secondary oocyte primary oocyte choroid plexus of fourth ventricle jejunum lactiferous gland duodenum right kidney calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Arp2/3 complex binding 1-phosphatidylinositol binding protein binding phosphatidylinositol binding ubiquitin protein ligase binding lipid binding cadherin binding identical protein binding Cellular component cytoplasm Golgi apparatus cell projection membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane trans-Golgi network extracellular exosome cytoplasmic vesicle membrane clathrin-coated vesicle cytosol cytoplasmic vesicle cuticular plate Biological process endocytosis cleavage furrow formation mitotic cytokinesis positive regulation of membrane protein ectodomain proteolysis receptor-mediated endocytosis plasma membrane tubulation cell division endosomal transport positive regulation of GTPase activity positive regulation of protein oligomerization protein transport lipid tube assembly cell cycle intracellular protein transport positive regulation of protein kinase activity membrane organization mitotic cell cycle transport positive regulation of actin filament polymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51429 66616 Ensembl ENSG00000130340 ENSMUSG00000002365 UniProt Q9Y5X1 Q91VH2 RefSeq (mRNA) NM_016224 NM_025664 RefSeq (protein) NP_057308 NP_079940 Location (UCSC) Chr 6: 157.7 – 157.95 Mb Chr 17: 5.89 – 5.98 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.^[7]

Interactions

SNX9 has been shown to interact with ADAM9,^[5] DNM2^[8] and ADAM15.^[5]